Synthesis of (+)-Coronafacic Acid

摘要

An enantioselective synthesis of (+)-coronafacic acid has been achieved. Rhodium-catalyzed cyclizationof an a-diazoester provided the intermediate cyclopentanone in high enantiomeric purity. SubsequentFe-mediated cyclocarbonylation of a derived alkenyl cyclopropane gave a bicyclic enone that then washydrogenated and carried on to the natural product.