Functionalized Chiral Ionic Liquid Catalyzed Enantioselective Desymmetrizations of Prochiral Ketones via Asymmetric Michael Addition Reaction

摘要

Functionalized chiral ionic liquids were found to be highly effective and reusable organocatalysts for asymmetric Michael additions of 4-substituted cyclohexanones. The desymme-trization reaction afforded the desired Michael adducts bearing three carbon stereocenters with up to 99% ee.