Prolinethiol ether catalysis in an asymmetric michael reaction: Solvent-free synthesis of functionalized monohaloalkenes

摘要

The organocatalytic Michael reaction of ketones with γ- monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.