Sodium hydroxide catalyzed N-alkylation of (hetero) aromatic primary amines and N_1,C_5-dialkylation of 4-phenyl-2-aminothiazoles with benzyl alcohols

摘要

In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. With 1 equiv of NaOH, N_1,C_5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N_1,C_5-dialkylated products through hydride ion transformation from alcohol.