Synthesis of acyclic nucleosides with a chiral amino side Chain by the mitsunobu coupling reaction

摘要

Figure presented A novel and efficient synthetic method has been developed for the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected l-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.