Aldehyde- and Ketone-Induced Tandem Decarboxylation-Coupling (Csp3-Csp) of Natural a-Amino Acids and Alkynes

摘要

An interesting aldehyde- and ketone-induced intermolecular tandem decarboxylation-coupling (Csp3-Csp) catalyzed by copper with use of natural ct-amino acids as starting materials is developed under neutral conditions with the production of CO2 and H20 as the only byproducts. Various functionalized nitrogen-containing compounds were obtained by this method. In these processes, interesting regioselectivites of the alkylation were observed, which has been rationalized by the relative stability of proposed resonance structures based on computation methods.