Heterocyclization of 3-aminocamphor and 3-aminoisoborneol derivatives with cyclic βdiketones and formaldehyde. synthesis of optically active 1, 2, 3, 4-tetrahydroquinoline derivatives with terpene substituents

摘要

Spirocyclic 1, 2, 3, 4-tetrahydroquinoline derivatives were prepared in quantitative yield by three-component condensation of dimedone or Meldrum's acid with formaldehyde and (1S, 3R, 4S)-1, 7, 7-trimethyl-3- (arylamino)bicyclo[2.2. 1]heptan-2-one or (1S, 2S, 3R, 4S)-1, 7, 7-trimethyl-3-(arylamino)bicyclo[2.2.1] heptan- 2-ol.