Investigation of the Interaction between Simple Micelles and Mixed Micelles in Taurocholate-Lecithin Solutions by Laser Light Scattering

摘要

A laser light-scattering technique was employed to investigate simple micelles and mixed micelles thermodynamically coexisting in various taurocholate (TC)-lecithin (L) solutions. When the nonmixed micellar TC (NMTC) concentration were higher than 25 mM for L = 12 mM and 21 mM, the sizes of simple TC micelles (～10 A) and mixed TC-L micelles (～24 A) as well as the polydispersity (～45%) of these micelles were nearly unchanged. At a constant concentration of L, the average size decreased and, more notably, the total scattered intensity also decreased with increasing concentrations of TC. A modified physical equation successfully modeled the scattered intensity versus different concentrations of simple TC micelles and mixed TC-L micelles. Moreover, a strong interaction between simple TC micelles and mixed TC-L micelles was found which appeared to be a process for the transfer of cholesterol molecules in the cholesterol gallstone dissolution.