Varenicline, Appetite, and Weight Reduction

摘要

To the Editor. Nicotine is possibly one of the most prevalent dependence-producing drugs because of the central nicotinic-cholinergic, dopaminergic, serotonergic, and gaba-minergic pathways with which it has been associated. Nicotine-dependent behavior may conceivably be reinforced by the drug's focus and memory enhancing properties, as well as antidepressant, anxiolytic, and appetite-suppressing properties. Nicotine is a unique paradigm in that it suppresses appetite and stabilizes mood. Nicotine withdrawal leads to the emergence of craving in dependent individuals, which can include impaired memory and concentration, depressed mood, anxiety, and increased appetite.