Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse.

摘要

TO THE EDITOR:Skin hairs develop in a highly coordinated manner, and a complex genetic program controls their size, texture, density, and patterns (Schmidt-Ullrich and Paus, 2005; Sick etal, 2006; Schlake, 2007). In addition to their physical features, hairs are distributed in macroscopic patterns. In rodents, all body hairs are oriented caudal ly and those on the feet are pointed distally. Here, we report that hair patterning on the body and legs in mice are disturbed by targeted inactivation of Celsr1, a seven-pass cadherin (Celsr) that is homologous to the Drosophila planar cell polarity (PCP) protein Flamingo/ Starry night (Fmi/Stan; Strutt and Strutt, 2007).