CONSTITUENTS OF Mikania lasiandrae

摘要

Mikania Wild is the only genus in the subtribe Mikaniinae of the tribe Eupatorieae. It is represented by 415 species distributed mainly in Central and South America, with 171 species occurring in Brazil [1]. M. glomerata Spreng. (Compositae) is known popularly as "guaco" or "guaco-cheiroso" [2]. It is used in folk medicine for the treatment of the fever, rheumatism, and illnesses of the respiratory tract [ 3]. Pharmacological studies have confirmed the anti-inflammatory properties of the crud e extract of the guaco, while chemical studies point to coumarins and enr-kaurenoic acid as the main constituents of this species [4, 5]. The occurrence of kaurane-type diterpenes and sesquiterpene lactones is very common in this genus [6, 7]. Diterpenes are predominant in the chemical composition of Brazilian Mikania [8]. The absence of chemical studies of M. lasiandrae DC, related to the necessity for a chemosystematic study of endemic species of the Brazilian flora, today considered a seriously threatened ecosystem, prompted us to isolate and identify the constituents of this species.