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首页> 外文期刊>Chinese journal of digestive diseases >Experimental study of the safety of the selective COX-2 inhibitor, celecoxib, for gastric mucosa
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Experimental study of the safety of the selective COX-2 inhibitor, celecoxib, for gastric mucosa

机译：选择性COX-2抑制剂塞来昔布对胃黏膜安全性的实验研究

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OBJECTIVE: To compare the gastric mucosal damage induced by a COX-2 inhibitor, celecoxib, and a conventional NSAID, indomethacin.METHODS: A rat model of NSAID-induced gastric mucosal damage was prepared for indomethacin and celecoxib separately (n = 8). After gastric damage was induced by 100% ethanol, celecoxib was administered by gastric gavage (n = 8). Gastric mucosal concentrations of 6-keto-PGF_lalpha and TXB_2 and the lesion index (LI) were measured. Morphological changes of the gastric mucosa were assessed under light and scanning electron microscopy.
机译：目的：比较COX-2抑制剂塞来昔布和常规NSAID对吲哚美辛诱导的胃粘膜损害。方法：分别制备了NSAID诱导的胃粘膜损害的吲哚美辛和塞来昔布大鼠模型（n = 8）。用100％乙醇诱导胃损伤后，通过胃管灌胃塞来昔布（n = 8）。测量了6-酮-PGF_1α和TXB_2的胃粘膜浓度和病变指数（LI）。在光学和扫描电子显微镜下评估胃粘膜的形态变化。

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