Synthesis of glycyrrhizic acid conjugates containing L-lysine

摘要

Activated esters and N-hydroxybenzotriazole-N,N'-dicyclohexylcarbodiimide (DCC) or N-hydroxysuccinimide-DCC were used to synthesize conjugates of glycyrrhizic acid (GA) with N-epsilon-carbobenzyloxy-L-lysine [Lys(Z)-OH] and its esters containing two or three amino components. It was shown that the conjugate of GA 30-methyl ester with Lys(Z)-OH possessed anti-HIV-1 activity.