Synthesis and biological activity of 3,4-dihydropyrimidin-2-thione aminomethylene derivatives based on the alkaloid cytisine

摘要

3,4-Dihydropyrimidin-2-thiones derivatized by the alkaloid cytisine were synthesized by Mannich aminomethylation. The compositions and structures of the products were confirmed by mass spectrometry and PMR and ~1H- ~1H NOESY spectroscopy. One of the products showed pronounced antimicrobial activity.