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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Increased incidence of bronchopulmonary dysplasia in preterm infants exposed to preeclampsia
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Increased incidence of bronchopulmonary dysplasia in preterm infants exposed to preeclampsia

机译:子痫前期暴露的早产儿支气管肺发育不良的发生率增加

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摘要

Objective: The aims of the study were to determine the effect of preeclampsia on bronchopulmonary dysplasia (BPD) development in preterm infants and to investigate the possible association between BPD severity and preeclampsia. Methods: The study group involved preterm infants (≤32 gestational week) born to a preeclamptic mother with no co-existing medical condition, whereas the comparison group involved preterm infants born to a normotensive mother. BPD was defined as requirement for supplemental oxygen for the first 28 days of life and classified as mild, moderate and severe. Results: There were a total of 117 and 215 premature infants that were born to a preeclamptic mother and a normotensive mother, respectively. The incidence of BPD in preterm infants born to preeclamptic mothers (38.5%) was significantly higher than those born to normotensive mothers (19.5%). Frequencies of moderate and severe BPD were significantly higher in the infants born to preeclamptic mothers. Moderate and severe BPD was also significantly higher in infants born to a mother with severe preeclampsia compared with a mother with mild preeclampsia. In logistic regression model, preeclampsia was found to be predictive of BPD. Conclusions: Preeclampsia was found to be an important risk factor for BPD development in preterm infants. The incidence of both moderate and severe BPD was significantly higher in infants born to preeclamptic mothers. These findings might be associated with altered angiogenesis in the preeclamptic mother which might be shared by the fetus.
机译:目的:本研究的目的是确定先兆子痫对早产儿支气管肺发育不良(BPD)发展的影响,并探讨BPD严重程度与先兆子痫之间的可能关系。方法:研究组包括先兆子痫母亲(≤32孕周),无先天合并疾病,而对照组则包括正常血压母亲的早产儿。 BPD被定义为生命最初28天补充氧气的要求,分为轻度,中度和重度。结果:总共有117名和215名早产儿分别来自先兆子痫和正常血压的母亲。子痫前期母亲所生的早产儿的BPD发生率(38.5%)显着高于血压正常母亲所生的早产儿(19.5%)。先兆子痫母亲所生婴儿的中,重度BPD频率明显更高。与患有轻度先兆子痫的母亲相比,患有重度子痫前期的母亲所生的婴儿的中度和严重BPD也显着更高。在逻辑回归模型中,先兆子痫可预测BPD。结论:子痫前期被发现是早产儿BPD发生的重要危险因素。先兆子痫母亲出生的婴儿中,重度BPD的发生率明显更高。这些发现可能与子痫前期母亲血管新生的改变有关,可能与胎儿共有。

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