Likelihood to be helped or harmed can assist in clinical decision-making.

摘要

To the Editor: Gao and colleagues' number-needed-to-treat analysis of the atypical antipsychotics was read with great interest. Perhaps the biggest public health impact is in the treatment of major depressive disorder (MDD), a common disorder for which the US Food and Drug Administration has approved 3 different antipsychotic agents to be used with antidepressants. The authors' results are similar to what I have previously reported, and what remains striking is how commonly certain adverse events can be encountered: somnolence or sedation with quetiapine, weight gain with olanzapine, and akathisia with aripiprazole.