Treatment of hidradenitis suppurativa: Is oral isoniazid an option?

摘要

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating follicular skin disease that usually presents after puberty with painful deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axillary, inguinal and anogenital regions . The prevalence is approximately 1 % and quality of life is severely affected . The pathogenesis remains unclear. However, involvement of the apocrine glands, dysregulated immune response in the hair follicles, occlusion of the follicular infundibulum, bacterial infection and bacteria-induced immuno-modulation are all suspected to play a role. Microorganisms such as Staphylococcus aureus and anaerobe bacteria can be isolated from lesions, but often the lesions appear sterile. HS is currently considered a sterile inflammation, and the bacteria are suspected to act as immunomodulators in the infiammationprocess .