Vitamin E supplementation in old mice induces antimicrobial activity and improves the efficacy of daptomycin in an animal model of wounds infected with methicillin-resistant Staphylococcus aureus.

摘要

Antibiotic-resistant bacteria, such as methicillin-resistant Sta-phylococcus aureus (MRSA), are a recognized problem in healthcare settings, leading to refractory infections and potentially life-threatening illnesses.1 MRSA is often isolated from patient wounds in both the hospital and the community setting. A variety of factors determine whether a wound remains harmlessly colonized or succumbs to infection. Some of the most important factors include individual vulnerability to infection and the size and location of the wound, balanced against the number of microorganisms present and their virulence factors. Vulnerability factors include age, with the elderly being more prone to MRSA infection as they have a compromised immune response (immunosenescence), and underlying diseases, such as diabetes or cardiovascular disease, and malnutrition, all of which affect the wound-healing process.