SUBSTITUTED 2-FORMYLBENZOIC ACIDS IN THE SYNTHESIS OF 11H-ISOINDOLO[2,1-a]BENZIMIDAZOL-11-ONES, 5H-ISOINDOLO[2,1-a][3,1]BENZOXAZINE-5,11(6aH)-DIONES, AND 6,6a-DIHYDROISOINDOLO-[2,1-a]QUINAZOLINE-5,11-DIONES

E. V. Gromachevskaya; A. V. Finko; A. V. Butin; K. S. Pushkareva; V. D. Strelkov; L. I. Isakova; G. D. Krapivin

首页> 外文期刊>Chemistry of heterocyclic compounds >SUBSTITUTED 2-FORMYLBENZOIC ACIDS IN THE SYNTHESIS OF 11H-ISOINDOLO[2,1-a]BENZIMIDAZOL-11-ONES, 5H-ISOINDOLO[2,1-a][3,1]BENZOXAZINE-5,11(6aH)-DIONES, AND 6,6a-DIHYDROISOINDOLO-[2,1-a]QUINAZOLINE-5,11-DIONES

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SUBSTITUTED 2-FORMYLBENZOIC ACIDS IN THE SYNTHESIS OF 11H-ISOINDOLO[2,1-a]BENZIMIDAZOL-11-ONES, 5H-ISOINDOLO[2,1-a][3,1]BENZOXAZINE-5,11(6aH)-DIONES, AND 6,6a-DIHYDROISOINDOLO-[2,1-a]QUINAZOLINE-5,11-DIONES

机译：合成11H-异吲哚并[2,1-a]苯并咪唑-11-酮，5H-异吲哚并[2,1-a] [3,1]苯并嗪-5,11（6aH）-二酮取代的2-甲酰基苯甲酸和6,6a-二氢异吲哚-[2,1-a]喹唑啉-5,11-二酮

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Optimal conditions were developed for the synthesis of 11H-isoindolo[2,1-a]benzimidazol-11-one, 5H-isoindolo[2,1-a][3,1]benzoxazine-5,11(6aH)-dione, and 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives in the reaction of substituted 2-formylbenzoic acids with o-phenylenediamine, anthranilic acid, and anthranilamide, respectively. The bifolded structure of 6,6a-dihydroisoindolo-[1,2-a]quinazoline-5,11-dione was verified and investigated.

机译：为合成11H-异吲哚并[2,1-a]苯并咪唑-11-one，5H-异吲哚并[2,1-a] [3,1]苯并恶嗪-5,11（6aH）-二酮开发了最佳条件，和6,6a-二氢异吲哚并[2,1-a]喹唑啉-5,11-二酮衍生物在取代的2-甲酰基苯甲酸与邻苯二胺，邻氨基苯甲酸和邻氨基苯甲酰胺的反应中。验证和研究了6,6a-二氢异吲哚并[1,2-a]喹唑啉-5,11-二酮的双折叠结构。

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《Chemistry of heterocyclic compounds》 |2013年第9期|共14页
作者
E. V. Gromachevskaya; A. V. Finko; A. V. Butin; K. S. Pushkareva; V. D. Strelkov; L. I. Isakova; G. D. Krapivin;
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正文语种 eng
中图分类杂环化合物;
关键词
anthranilamide; anthranilic acid; 2-formylbenzoic acid; isoindolone; o-phenylenediamine; heterocyclization domino reaction; N; N-bis-nucleophiles; N; O-bis-nucleophiles;

机译：邻氨基苯甲酰胺;邻氨基苯甲酸;2-甲酰基苯甲酸;异吲哚酮;邻苯二胺;杂环多米诺反应;N;N-双亲核试剂;N;O-双亲核试剂;

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1. SUBSTITUTED 2-FORMYLBENZOIC ACIDS IN THE SYNTHESIS OF 11H-ISOINDOLO[2,1-a]BENZIMIDAZOL-11-ONES, 5H-ISOINDOLO[2,1-a][3,1]BENZOXAZINE-5,11(6aH)-DIONES, AND 6,6a-DIHYDROISOINDOLO-[2,1-a]QUINAZOLINE-5,11-DIONES [J] . E. V. Gromachevskaya, A. V. Finko, A. V. Butin, Chemistry of heterocyclic compounds . 2013,第9期

机译：合成11H-异吲哚并[2,1-a]苯并咪唑-11-酮，5H-异吲哚并[2,1-a] [3,1]苯并嗪-5,11（6aH）-二酮取代的2-甲酰基苯甲酸和6,6a-二氢异吲哚-[2,1-a]喹唑啉-5,11-二酮
2. Studies on novel synthetic methodologies, part XII: An efficient one-pot access to 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-phenylisoindolo[2,1-a]quinazolin-11(6a H)-ones [J] . Sashidhara K.V., Palnati G.R., Dodda R.P., Synlett . 2013,第1期

机译：新型合成方法的研究，第十二部分：有效一锅获得6,6a-dihydroisoindolo [2,1-a] quinazoline-5,11-diones和5-phenylisoindindolo [2,1-a] quinazolin-11（ 6a H）-个
3. β-Cyclodextrin mediated MCR in water: synthesis of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives under microwave irradiation [J] . G. Rajeshwar Reddy, T. Ram Reddy, R. Gangadhara Chary Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2013,第49期

机译：水中β-环糊精介导的MCR：微波辐射下二氢异吲哚并[2,1-a]喹唑啉-5,11-二酮衍生物的合成
4. Dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives as potent and selective inhibitors targeting hepatitis B virus [O] . Jun-Fei Zhang, Bo Liu, Cong-Xin Chen 2015

机译：Dihydroisoindolo [2,1-a]喹唑啉-5,11-二酮衍生物作为针对乙型肝炎病毒的有效和选择性抑制剂

SUBSTITUTED 2-FORMYLBENZOIC ACIDS IN THE SYNTHESIS OF 11H-ISOINDOLO[2,1-a]BENZIMIDAZOL-11-ONES, 5H-ISOINDOLO[2,1-a][3,1]BENZOXAZINE-5,11(6aH)-DIONES, AND 6,6a-DIHYDROISOINDOLO-[2,1-a]QUINAZOLINE-5,11-DIONES

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