Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation

Cojutti Piergiorgio; Maximova Natalia; Crichiutti Giovanni; Isola Miriam; Pea Federico

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Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation

机译：利奈唑胺在住院儿科患者中的药代动力学/药效学评估：通过治疗药物监测和蒙特卡罗模拟朝着剂量优化的一步

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摘要

Objectives: To report on linezolid exposure in a paediatric population who routinely underwent therapeutic drug monitoring (TDM) for dosage optimization and to assess the factors affecting interpatient variability.

机译：目的：报告常规治疗药物监测（TDM）以优化剂量的儿科患者的利奈唑胺暴露情况，并评估影响患者间变异性的因素。

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来源
《The Journal of Antimicrobial Chemotherapy》 |2015年第1期|共9页
作者
Cojutti Piergiorgio; Maximova Natalia; Crichiutti Giovanni; Isola Miriam; Pea Federico;
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正文语种 eng
中图分类治疗学;
关键词
MDR staphylococci; oxazolidinones; drug interactions; drug underexposure;

机译：耐多药葡萄球菌;恶唑烷酮;药物相互作用;药物接触不足;

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1. Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation [J] . Cojutti Piergiorgio, Maximova Natalia, Crichiutti Giovanni, The Journal of Antimicrobial Chemotherapy . 2015,第1期

机译：利奈唑胺在住院儿科患者中的药代动力学/药效学评估：通过治疗药物监测和蒙特卡罗模拟朝着剂量优化的一步
2. Optimizing the dosing regimen of linezolid in critically ill septic patients undergoing continuous hemodiafiltration using a pharmacokinetic/pharmacodynamic analysis and monte carlo simulation [J] . H Barrasa González, A Martín López, A Isla Ruiz, Intensive Care Medicine Experimental . 2015,第S1期

机译：使用药代动力学/药效学分析和蒙特卡洛模拟优化连续性血液透析滤过的危重脓毒症患者利奈唑胺的给药方案
3. Optimizing ciprofloxacin dosing in intensive care unit patients through the use of population pharmacokinetic–pharmacodynamic analysis and Monte Carlo simulations [J] . Dalia Khachman, Jean-Marie Conil, Bernard Georges, Journal of Antimicrobial Chemotherapy . 2011,第8期

机译：通过使用人群药代动力学-药效学分析和蒙特卡洛模拟，优化重症监护病房患者的环丙沙星剂量
4. Optimization of image quality and patient dose in paediatric radiology using Monte Carlo modeling [C] . P. Penchev, V. Klingmtiller, G. Alzen European Conferenc of the International Federation for Medical and Biological Engineering . 2008

机译：利用蒙特卡罗建模优化儿科放射学的图像质量和患者剂量
5. Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations. [D] . Mohamed, Osama H. 2004

机译：临床药代动力学模拟/建模，作为特殊患者人群中治疗药物监测和剂量调整的工具。
6. Optimizing the dosing regimen of linezolid in critically ill septic patients undergoing continuous hemodiafiltration using a pharmacokinetic/pharmacodynamic analysis and monte carlo simulation [O] . H Barrasa González, A Martín López, A Isla Ruiz, 2015

机译：使用药代动力学/药效学分析和蒙特卡洛模拟优化连续性血液透析滤过的危重脓毒症患者利奈唑胺的给药方案
7. Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation [O] . P. Cojutti, N. Maximova, G. Crichiutti, 2014

机译：用于住院儿科患者的LINZOLID的药代动力学/药效学评价：通过治疗药物监测和蒙特卡罗模拟探讨剂量优化的步骤

Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation

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