Detection of a Shiga toxin- and extended-spectrum-β-lactamase-producing Escherichia coli o157: H7 human clinical isolate

摘要

Sir, Shiga toxin-producing Escherichia coli (STEC) is recognized as an important human pathogen that continues to be one of the major causes of food- and waterborne outbreaks. Human infection with STEC is potentially fatal and may be associated with a wide range of symptoms, from uncomplicated diarrhoea to haemorrhagic colitis and haemolytic uraemic syndrome. E. coli isolates resistant to oxyimino cephalosporins due to the production of extended-spectrum beta-lactamases (ESBLs) have emerged worldwide and a number of different ESBL genes such as bla_(SHV),bla_(TEM) and bla_(CTX-M) have been identified from infections in humans as well as in animals.2 Until recently there have only been a few reports of ESBL-producing STEC strains isolated from humans or animals, including the outbreak in May and June 2011 in which an ESBL-producing enteroaggregative E. coli (EAEC) STEC O104:H4 infected 3793 patients in Germany