Synthesis and Cytotoxicity of Derivatives of Di(3-indolyl) Selenide

摘要

A method has been developed for the synthesis of di(3-indolyl) selenides. From indole and SeO_2. N-Alkyl derivatives of di(3-indolyl) selenide have been obtained in the two-phase system alkyl halide–solid K_2CO_3 (or KOH)–18-crown-6–toluene. It was discovered that N-unsubstituted di(3-indolyl) selenides possess high cytotoxicity on HT-1080 and MG-22A tumor cell lines.