POLYCYCLIC SYSTEMS CONTAINING 1,2,4-OXADIAZOLE RING 2. 4-(1,2,4-OXADIAZOL-5-YL)PYRROLIDIN-2-ONES: SYNTHESIS AND PREDICTION OF BIOLOGICAL ACTIVITY

摘要

A one-pot condensation of 5-oxopyrrolidine-3-carboxylic acids, carbonyldiimidazole, and benzamidoximes leads to the formation of the novel 4-(1,2,4-oxadiazol-5-yl) pyrrolidin-2-one bicyclic systems, the structures of which have been confirmed by IR and H-1 NMR methods and by liquid chromato-mass spectrometry. The results of a PASS prediction of the biological activity of the synthesized compounds are presented.