Interrupting IL-6-receptor signaling improves atopic dermatitis but associates with bacterial superinfection.

摘要

Atopic dermatitis is a multifactorial disorder associated with T_H2-polarized CD4~+ T cells that can overproduce IL-6, IL-5, IL-4, and IL-13.IL-6 is secreted by activated T cells and macro-phages. It regulates the immune response, inflammation and pathogen responses, bone metabolism, and hematopoiesis.