We thank the authors for their comment on our study of Trich-uris suis ova for the treatment of allergic rhinitis.The study was a randomized, double-blind, placebo-controlled clinical trial in which 96 subjects with grass pollen allergy received 8 treatments with 2,500 T suis ova or placebo.We observed no beneficial clinical effect on their pollen allergy, as well as no subclinical effect after 6 months (168 days).The comments by Hepworth et al mainly concern the future of the use of parasite therapy in preventing the development of allergic disease (eg, the treatment of nonallergic children). Our study did not address this issue because all subjects had allergy. We encourage studies on this hypothesis despite our negative result.
展开▼
机译：我们感谢作者对我们的Trich-uris suis ova治疗变应性鼻炎的评论2,500 T suova ova或安慰剂。我们未观察到对其花粉过敏的有益临床作用，在6个月（168天）后也未见亚临床作用。过敏性疾病的发展（例如，非过敏性儿童的治疗）。我们的研究未解决此问题，因为所有受试者均过敏。尽管我们的结果是负面的，但我们仍鼓励对此假设进行研究。
展开▼
