Systemic therapies for severe atopic dermatitis in children and adults

摘要

A 12-year-old boy was referred to a tertiary pediatric dermatology center with a lifelong history of severe atopic dermatitis (AD) (see Fig El in this article's Online Repository at www. jacionline.org). He had lately missed several weeks of school because of hospital admissions for recurrent skin infections, lack of sleep, and intense discomfort. Over the years, he had primarily been taking regular emollients and potent topical steroids and, more recently, underwent a failed trial of UV phototherapy. Intense topical steroid therapies, wet wraps with emollient overnight, after-treatment education on the day ward, and a prolonged course on oral antibiotics did not result in sustained improvement.