TGF-??1 polymorphisms and asthma severity, airway inflammation, and remodeling

摘要

The development and progression of asthma are determined by multiple genetic and environmental factors. A relatively new hypothesis is that chronic injury by environmental irritants and/or defective repair of the airway epithelium leads to the release of cytokines and growth factors. These factors drive chronic airway inflammation and remodeling seen in asthma. Airway inflammation and remodeling are 2 important pathologic features associated with airway hyperresponsiveness (AHR) and fixed airflow obstruction.