Component-resolved diagnosis of peach allergy and its relationship with prevalent allergenic pollens in China

摘要

Today, molecule-based component-resolved diagnosis is more commonly used because of its advantage in distinguishing species-specific allergens from cross-reactive allergens and predicting the potential risk of severe reactions. Sensitization patterns of foods comprising the component allergens and relevant manifestations exhibit obvious geographic differences.1'2 Peach allergy is common in China; however, the sensitization to peach allergens and the relevance of the sensitization pattern for the clinical presentation remain unclear.The most important peach allergens, Pru p 1, Pru p 3, and Pru p 4, belong to the protein family of pathogenesis-related protein 10 (PR-10), nonspecific lipid transfer protein (nsLTP), and profilin, respectively. It is well known that PR-10-related oral allergy syndrome usually follows birch pollen sensitization.The nsLTPs used to be considered pollen-unrelated "true" food allergens. However, Platanus acerifolia, Olea europaea, and mugwort pollen nsLTPs were successively reported to have a close relationship with peach nsLTP, namely Pru p 3, despite the controversy on the initiation pathway of primary sensitization.