Expression of mast cell-associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy.

摘要

To the Editor: Eosinophilic esophagitis (EoE) is an eosinophil-dominated disease seen in the esophagi of both children and adults. Despite many similarities, differences exist between pediatric and adult EoE. Adults with EoE typically present with dysphagia and food impaction, whereas children present with failure to thrive or vomiting. Patients with EoE often have a personal and family history of atopic disease. We previously reported differences in the patterns of allergic predisposition between adult and pediatric EoE. Adults with EoE often have specific IgE for food allergens, aeroallergens, or both but rarely have a history of food-induced anaphylaxis.