Risk of congenital malformations for asthmatic pregnant women using a long-acting beta(2)-agonist and inhaled corticosteroid combination versus higher-dose inhaled corticosteroid monotherapy

摘要

Background: Current recommendations for managing persistent asthma during pregnancy when low-dose inhaled corticosteroids (ICSs) are insufficient include adding a long-acting beta(2)-agonist (LABA) or increasing the ICS dose. However, there are no data to help clinicians evaluate the safest regimen during pregnancy.