Pharmacokinetics and milk concentration of pefloxacin injection (Pelwin) in lactating cows.

摘要

Blood and milk samples were collected from 8 clinically healthy lactating cows at 5 intervals up to 45 min and at 8 intervals from 1 to 24 h after they were given an i.v. injection of 5 mg/kg pefloxacin. The therapeutic plasma concentration of the drug (0.03 to 2 mug/ml) was maintained for up to 4.5 h. The distribution half life, elimination half life, total body clearance, and volume of distribution, respectively, were 0.15 +- 0.03 h, 2.53 +- 0.09 h, 3.67 +- 0.04 ml/min per kg, and 0.68 +- 0.03 litres/kg. The mean peak milk concentration was 4.14 mug/ml.