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Common mechanisms for boundary formation in somitogenesis and brain development: shaping the 'chic' chick

机译:体细胞生成和大脑发育中边界形成的常见机制:塑造“别致”小鸡

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摘要

When organs and tissues acquire their characteristic shapes and functions during early development, boundaries are established that distinguish between and delimit distinct areas. Such boundaries are not mere edges, but also play important roles as secondary signaling centers in subsequent morphogenesis. Following on pioneering findings provided by studies in Drosophila, the mechanisms underlying boundary formation in vertebrate embryogenesis have attracted the interest of an increasing number of researchers. Somitogenesis and brain development, in particular, serve as model systems for the study of the molecular and cellular events occurring at developing boundaries. Recent findings allow us to draw some general pictures concerning the shared mechanisms that participate in these processes of organogenesis, in which Notch, Eph/ephrin and cadherin-mediated signaling are among the main key regulators.
机译:当器官和组织在早期发育过程中获得其特征形状和功能时,就会建立区分和界定不同区域的边界。这样的边界不仅是边缘,而且在随后的形态发生中作为次级信号传导中心也起着重要的作用。继果蝇研究提供的开创性发现之后,脊椎动物胚胎发生中边界形成的基础机制引起了越来越多研究人员的兴趣。尤其是,体细胞发生和大脑发育是研究在发展中边界发生的分子和细胞事件的模型系统。最近的发现使我们能够得出关于参与这些器官发生过程的共有机制的一般情况,其中Notch,Eph / ephrin和cadherin介导的信号传导是主要的关键调控因子。

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