Opsoclonus-myoclonus with multiple paraneoplastic syndromes and VGCC antibodies.

摘要

Current evidence suggests that neurological paraneoplastic syndromes are clinical entities in which antibodies directed against tumor epitopes cross-react with native antigens within the nervous system. Recent evidence suggests that many antibodies are not exclusively associated with a particular syndrome, and that particular antibodies may be more indicative of the underlying malignancy than a specific neurological disorder. They may serve a protective role in controlling neoplastic growth and spread as the neurological syndrome almost always appears (up to months or years) prior to identification of the underlying tumor.