Changes in endometrial histology following enrofloxacin therapy in crossbred cows suffering from endometritis.

摘要

The histopathological changes in the endometrium following enrofloxacin therapy were studied in crossbred cows in India suffering from endometritis. Twelve cows (Group A) were treated with intrauterine enrofloxacin (1000 mg in 30 ml distilled water) for 3 consecutive days, while the other 12 cows (Group B) were infused with 20 ml of PBS in an identical schedule. Endometrial biopsies were collected prior to and at 72 h after treatment from all cows for histopathological studies. It was shown that enrofloxacin treatment caused histopathological changes. The effects were evident by an additional increase of 25% cows showing denuded epithelium at 72 h post-treatment. Furthermore, a poor recovery of cases with pseudostratification with reduced cellular infiltration following antibiotic treatment indicated an adverse effect of enrofloxacin on uterine defence mechanism. On the other hand, infusion of PBS did not cause any such changes in endometrial epithelium of cows under control group. However, PBS reduced the number of cases with denuded epithelium with an appreciable increase in the infiltration of mononuclear and PMN cells. In conclusion, intrauterine infusion of enrofloxacin may cause changes in endometrial histology and have some adverse effect on uterine defence mechanism in the cows suffering from endometritis.