Chronic interstitial pneumonitis in end-stage sarcoidosis.

摘要

End-stage sarcoidosis is typically characterised by severe interstitial fibrosis occurring along the bronchovascular bun dles with cystic changes [1, 2], Chronic interstitial pneumonitis typically occurs in the early stages of sarcoidosis and is localised to the areas affected by granulomas [3-5]. Herein, we report end-stage sarcoidosis patients who underwent lung transplantation at our centre (University of Southern California, Keck School of Medicine, Los Angeles, CA, USA) and who surprisingly had evidence of moderate-to-severe chronic interstitial pneumonitis, which was previously con sidered atypical in end-stage sarcoidosis. Furthermore, two patients had a pattern resembling usual interstitial pneumoni tis (UIP) with fibroblastic foci.