Intracystic papillary carcinoma of breast harbors significant genomic alteration compared with intracystic papilloma: genome-wide copy number and LOH analysis using high-density single-nucleotide polymorphism microarrays.

摘要

To the Editor:Intracystic papillary breast tumors (ICPT) consist of benign papillomas, carcinomas in situ, and carcinomas with invasion, and they account for approximately 10% of benign breast tumors and less than 1% of malignant tumors, respectively (1,2). In breast lesions, indication for surgery is usually determined by pathological diagnosis together with radiologic findings, but differential, preoperative diagnosis of papillary carcinoma from papilloma is very difficult, even following needle biopsy (3) because of their nonspecific radio-logic characteristics and their modest cytological and histologic appearance (4). To avoid excessive surgical intervention, another diagnostic procedure needs to be developed.