Outcome of elderly breast cancer patients in china: the influence of prognostic factors and adjuvant systemic therapies.

摘要

Age is the greatest risk factors for the development of new breast cancer, and the incidence increases with age: 1 in 50 by age 50, 1 in 14 by age 70 and 1 in 9 by age 85 (1). Elderly breast cancer patients have more comorbid diseases (2), often been excluded from large randomized controlled trials (3,4). The optimal managements are still uncertain, but median life expectancy is as long as 14.8 years for women of 70 years, and still 8.4 years for women of 80 years, even though it is often underestimated by clinicians (5). Tumor features, as well as the influence of prognostic factors and adjuvant systemic therapies on survival, of elderly breast cancer in the Chinese population are still not reported. Furthermore, time distribution of tumor recurrence or mortality hazard in the elderly were still unknown. So this retrospective study was performed to analyze the outcome and survival pattern of elderly breast cancer patients in China, and to determine the influence of prognostic factors on survival and the efficiency of adjuvant systemic therapy.