SHRINKAGE OF DISPERSION PARAMETERS IN THE BINOMIAL FAMILY, WITH APPLICATION TO DIFFERENTIAL EXON SKIPPING

摘要

The prevalence of sequencing experiments in genomics has led to an increased use of methods for count data in analyzing high-throughput genomic data to perform analyses. The importance of shrinkage methods in improving the performance of statistical methods remains. A common example is gene expression data, where the counts per gene are often modeled as some form of an overdispersed Poisson. Shrinkage estimates of the per-gene dispersion parameter have led to improved estimation of dispersion, particularly in the case of a small number of samples.