THE SYNTHESIS OF (+/-)-HELIOTRIDANE AND (6S,7S)-DIHYDROXYHELIOTRIDANE VIA SEQUENTIAL HYDROGEN ATOM ABSTRACTION AND CYCLISATION

摘要

Treatment of N-(3-bromo-3-butenyl)pyrrolidine derivatives with tributyltin hydride and AIBN leads to hydrogen atom transfer of the intermediate vinyl radicals to give a-amino radicals which then cyclise stereoselectively yielding pyrrolizidines 1 and 13. Copyright (C) 1996 Elsevier Science Ltd [References: 25]