A simple solid-phase synthesis of disubstituted guanidines uisng Rink amide resin as an amine component

摘要

A practical solid-phase synthesis that simply uses Rink amide resin as an amine component in reacting with aromatic isothiocyanates and aliphatic amines to generate disubstituted guanidines is described.No special linker or gunaylation reagents are involved in this method.The product is obtained in a 'traceless-linker'fashion andin high yield and purity when an electron-deficient isothiocyanate is employed.