Control on enantioselectivity with pressure for lipase-catalyzed esterification in supercritical carbon dioxide

摘要

The enantioselectivity of lipase-catalyzed esterification of 1-(p-chlorophenyl)-2,2,2-trifluoroethanol in supercritical carbon dioxide changed continuously from E=10 to 50 by decreasing the pressure at 55deg C. The effect of the solvent on enantioselectivity was examined without changing the kind of solvent.