Control of enantioselectivity of lipase-catalyzed esterification in supercritical carbon dioxide by tuning the pressure and temperature

摘要

The enantioselectivity of lipase-catalyzed esterification of 1-(p-chlorophenyl)-2,2,2-trifluoroethanol in supercritical carbon dioxide was controlled by tuning the pressure and temperature. The enantioselectivity was higher at low pressure and low temperature (E=60) than at high pressure and high temperature (E=10). At the density of 0.75 g/mL, a modified Eyring plot of In E against 1/T was found to be linear, as expected from the theory on the effects of temperature on stereochemistry. (C) 2003 Published by Elsevier Science Ltd. [References: 28]