Highly selective directed hydrogenation of enantiopure 4-(tert-butoxycarbonylamino)cyclopent-1-enecarboxylic acid methl esters

摘要

The use of both N-tert-butoxycarbonylamino-and hydroxyl-directed hydorgenation methodology to yield essentially single diastereomers of 3-(tert-butoxycarbonylamino)-4-hydroxycyclopentanecarboxylic acid methyl esters and 3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid methyl esters is described.These results incorporate the first reported carbamate-directed hydrogenations of functionalised cyclopentenes.