Asymmetric synthesis of aziridine 2-phosphonates and azirinyl phosphonates from enantiopure sulfinimines

摘要

Enantiopure sulfinimine (S)-4 was employed in a Darzens-type synthesis of aziridine 2-phosphonates (-)-7/(+)-8 which were transformed into alpha-amino phosphonates (S)-11/(R)-12 and the first enantiopure examples of azirinyl phosphonates 13-15. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 28]