Conjugation of amino acid O-methyl esters with AZT-5'-O-phosphorothioate and phosphorodithioate

Janina Baraniak; Renata Kaczmarek; Wojciech J. Stec

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Conjugation of amino acid O-methyl esters with AZT-5'-O-phosphorothioate and phosphorodithioate

机译：氨基酸O-甲酯与AZT-5'-O-硫代磷酸酯和二硫代磷酸酯的缀合

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摘要

Based upon 1,3,2-oxathia-(dithia)phospholane chemistry, 5'-O-derivatisation of AZT with the O-methyl esters of L-phenylalanine and L-tryptophan was performed and the corresponding 5'-aminoacidophosphoramidothioates or phosphoramidodithioates of AZT were obtained in satisfactory yield.

机译：基于1,3,2-氧杂硫杂-（二硫杂）膦烷化学，进行了AZT与L-苯丙氨酸和L-色氨酸的O-甲酯的5'-O-衍生化反应，以及相应的5'-以令人满意的产率获得了AZT。

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来源
《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry 》 |2000年第47期| 共4页
作者
Janina Baraniak; Renata Kaczmarek; Wojciech J. Stec;
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正文语种 eng
中图分类有机化学 ;
关键词
AZT; N-phosphorothioylated amino acid; oxathia(-dithia)phospholane ring-opening condensation;

机译：AZT;N-硫代磷酸化的氨基酸;氧杂（-二硫）膦环开环缩合;

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1. Conjugation of amino acid O-methyl esters with AZT-5'-O-phosphorothioate and phosphorodithioate [J] . Janina Baraniak, Renata Kaczmarek, Wojciech J. Stec Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2000 ,第47期

机译：氨基酸O-甲酯与AZT-5'-O-硫代磷酸酯和二硫代磷酸酯的缀合
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4. Surface charge tunability as a powerful strategy to control electrostatic interaction for highly efficient delivery of nucleic acids, using tailored oligopeptide-modified poly(beta-amino ester)s (PBAEs) [C] . Pere Dosta, Nathaly Segovia, Victor Ramos, World biomaterials congress . 2016

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5. Indane 2,5-diketopiperazine synthons as probes of solid, solution and gas phase supramolecular non-covalent associations: Synthesis, characterization, and analysis of indane amino acids, unnatural bis-amino esters, indane 2,5-diketopiperazines, and indane bis 2,5-diketopiperazines. [D] . Kloster, Robin A. 2003

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7. Homologation of alpha-amino acids to beta-amino acids using Fmoc-amino acid pentafluorophenyl esters [O] . Sureshbabu, V.V., Gopi, H.N., Ananda, K. 1999

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8. Synthesis of Some N-Carboxy Methyl Amino Acid Esters and an Attempt to Prepare Di-(N-Carboxy Methyl Amino Acids Esters)-Sulphones for Possible Antimicrobial Activity [R] . Pasha, T. 1989

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Conjugation of amino acid O-methyl esters with AZT-5'-O-phosphorothioate and phosphorodithioate

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