Total synthesis of an anticancer agent, mucocin. 1. Stereoselective synthesis of the left-half segment

摘要

The left-half segment of mucocin (1) was stereoselectively synthesized through a coupling reaction of a tetrahydropyranyl aldehyde and a tetrahydrofuran derivative having an ethynyl group, which were prepared from 2,3,4,6-tetra-O-benzyl-D-galactono-1,5-lactone and 2,5-anhydro-D-mannitol, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 17]