The use of heterocycles for the conformational restriction of biologically active peptoids.

摘要

A series of piperazinone ring systems have been synthesised as a means of evaluating the effect of conformational restriction on high affinity non-peptide NK1, NK3 and CCK-B receptor ligands. The synthesis of the targeted heterocycles is described along with a discussion of their affinities for their respective receptor types. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 14]