FURTHER MODEL STUDIES RELATED TO FREDERICAMYCIN A - ANALOGUES IN WHICH RING C IS EXPANDED TO SIX ATOMS, AND AN EXAMINATION OF THE DIASTEREOSELECTIVITY OF RADICAL SPIROCYCLIZATION

摘要

The fredericamycin A analogues 5 and 23 were synthesized. A key step is the process of radical spirocyclization, and the diastereoselectivity of this reaction was studied with model compounds. In vitro tests showed that 23 was active against certain cell lines of colon and prostate cancer, while compound 5 was essentially inactive. (C) 1996 Elsevier Science Ltd. [References: 17]