Use of 7-Adamantyl-naphth-2-yl(hetero)aryl carboxylic acids, derivatives thereof (retinoid analogues) in preparing medicaments; compounds having a polyether radical bound to a moiety of at least two carbon atoms in position-beta

摘要

A retinoid analogue or a salt thereof or its chiral analogues has the formula (I) wherein: R1 is methyl, CH2OH, -OR3 or -CO-R4; Ar is a radical of formula (a) to (d); R2 is a polyether radical having carbon in the position a to the carbon which is in the 6th position of the naphthyl radical; R3 is H, alkyl or -(CH2)m(CO)n-R8; R4 is H, alkyl, -N(R')(R"), or -OR9; R5 is H or halogen, alkyl, hydroxy, -OR9 or -OCOOR10; R8 is alkyl or a saturated heterocycle; R9 is H, alkyl, alkenyl, mono- or polyhydroxyalkyl, optionally substituted aryl or aralkyl or a sugar residue, amino acid or peptide residue; R10 is alkyl; R' and R" are independently H, alkyl, mono- or polyhydroxyalkyl, optionally substituted aryl, or a sugar residue, amino acid or peptide residue or together can form a saturated heterocycle and m is 1 to 3. The compound is useful in treating disorders and/or aliments related to an over-regulation of RAR receptors and/or a hypervitaminosis A.