STUDIES ON TOTAL SYNTHESES OF ANTITUMOR STYRYLLACTONES - STEREOSELECTIVE TOTAL SYNTHESES OF (+)-GONIOFUFURONE, (+)-GONIOBUTENOLIDE A, AND (-)-GONIOBUTENOLIDE B

摘要

A highly stereoselective aldol reaction of the aldehyde 11, derived from (+)-tricarbonyl(eta(6)-2-trimethylsilylbenzaldehyde)chromium(0) complex (4), with 2-trimethysilyloxyfuran afforded the gamma-lactone derivative 13. The gamma-lactone 13 was subsequently convened into three antitumor styryllactones, (+)-goniofufurone, (+)-goniobutenolide A, and (-)-goniobutenolide B. Copyright (C) 1996 Elsevier Science Ltd [References: 44]